טיפול בתא לחץ ושיפור הפוריות

מתוך סקירת הספרות בנושא נמצאו 4 מאמרים הדנים בסוגיה-להן המאמרים : 1.Hyperbaric oxygen and ovarian follicular stimulation for in vitro fertilization: a pilot study. Van Voorhis BJ1, Greensmith JE, Dokras A, Sparks AE, Simmons ST, Syrop CH. Author information 1 Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA. brad-van-voorhis@uiowa.edu Abstract Our objective was to assess the safety and tolerability of hyperbaric oxygen therapy (HBO) as an adjunct to IVF therapy in women with a poor prognosis for pregnancy in a prospective observational pilot study. We conclude that HBO is well tolerated by women undergoing IVF treatment and that further study is required to determine whether this is an efficacious adjuvant therapy for women being treated by IVF 2.Improvement in Serum Anti-Müllerian Hormone Levels in Infertile Patients after Hyperbaric Oxygen (preliminary results). Pineda JF1, Ortiz CG1, Moguel Gde J1, Lopez CR2, Alcocer HM1, Velasco ST1. Author information 1 HISPAREP Fertility Clinic, Hospital Español, México DF. 2 Multidisciplinary Diabetes Center México City (Hyperbaric Chamber). Abstract OBJECTIVE: To assess whether hyperbaric oxygen sessions elevate serum levels of anti-Müllerian hormone (AMH) in patients diagnosed with infertility with serum levels of less than or equal to 1 ng/dl AMH. METHODS: A study was performed on 4 patients diagnosed with infertility. Serum AMH level was measured at the beginning and end of hyperbaric oxygen sessions, and endometrial thickness was measured on endometrial cycle day 14 before and during the hyperbaric oxygen sessions. RESULTS: In two of the four patients, the serum AMH level increased by 40% and 116%. In one patient the serum AMH level was not elevated, with a serum AMH level before and after treatment of 0.1 ng/dl. The fourth patient became pregnant during the hyperbaric oxygen sessions. Endometrial thickness was not improved in any of our patients. CONCLUSIONS: This study showed that hyperbaric oxygen sessions can increase serum AMH levels, with a significant increase of 116% in one case. Therefore, this therapy can be used as an alternative treatment for patients with serum AMH levels of less than or equal to 1 ng/dl and a limited number of eggs for IVF cycles but not for patients with serum AMH levels of less than or equal to 0.1 ng/dl, as we did not observe an increase in serum AMH level in patients with an initial AMH level of 0.1 ng/dl. This study did not demonstrate improvement in endometrial growth following hyperbaric oxygen sessions. 3.[HYPERBARIC OXYGEN THERAPY IN THE TREATMENT OF MALE INFERTILITY ASSOCIATED WITH INCREASED SPERM DNA FRAGMENTATION AND REACTIVE OXYGEN SPECIES IN SEMEN]. [Article in Russian] Metelev AY, Bogdanov AB, Ivkinl EV, Mitrokhin AA, Vodneva MM, Veliev EI. Abstract The aim of this study was to explore the potential of hyperbaric oxygenation (HBO) for reduction of sperm DNA fragmentation level and reactive oxygen species (ROS) in semen. The study included 90 men with idiopathic infertility. Patients of the treatment group (n = 60) underwent HBO before the vitro fertilization (IVF) procedure. In the control group (n = 30) IVF was carried out without prior cours of HBO. Sperm DNA fragmentation analysis was carried out using the TUNEL assay, the level of ROS in the ejaculate was measured by chemiluminescence. HBO treatment resulted in a significant decrease in the mean level of sperm DNA fragmentation from 33.2 ± 7.5 to 11.9 ± 5.9%, and the median ROS in sperm from 0.89 to 0.39 mV/s (p < 0.05). In the control group these changes were not statistically significant. Pregnancy after IVF occurred in 63.3% (38/60) of sexual partners of the treatment group men and in 36.7% (11/30) of the control group (p < 0.05). The high efficiency of HBO in overcoming the adverse effects of oxidative stress on sperm parameters allows us to consider it as a promising method for the treatment of men with idiopathic infertility. Bosn J Basic Med Sci. 2006 May;6(2):21-4. Hyperbaric oxygenation as a possible therapy of choice for infertility treatment. Mitrović A1, Nikolić B, Dragojević S, Brkić P, Ljubić A, Jovanović T. Author information 1 University Clinic of Gynecology and Obstetrics "Narodni front", Narodni front 62, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia and Montenegro. Abstract Endometrial sonographic and color doppler features can be used to predict the occurrence of pregnancy in natural or stimulated cycles. Implantation will usually only take place if the endometrium has reach a certain stage of vascularisation and development. The aim of this study was to evaluate endometrial development -- endometrial thickness and reflectivity , subendometrial, endometrial and uterine perfusion, after hyperbaric oxygenation, using transvaginal color doppler. During a three years period 32 women with unexplained infertility were entered into a randomised study. The patients were treated in multiplaced HAUX chamber at pressure of 2.3 ATA during 70 minutes, 7 days consecutively beginning with day 5th of menstrual cycle. The evaluation of effects of hyperbaric oxygen therapy was carried out by transvaginal color doppler sonography which was continuously used starting from 8th day of menstrual cycle until the ovulation in the cycles when the therapy was applied , one month before and one month after the therapy. Folliculometry in the cycles when hyperbaric oxygen therapy at 2.3 ATA was applied, indicated an excellent response of endometrium. Thickness of endometrium at the time of ovulation was 11.0 +/- 2.6 mm. Desirable quality of endometrium was significantly better in the cycle when HBO therapy had been applied (p< 0.001). The doppler flowmetry of the uterine arteries indicated that the uterine blood vessel resistance was slightly higher than expected. Mapping of subendometrial blood vessels in the cycles covered by hyperbaric oxygen therapy showed the intensive capillary network of endometrium with low resistance Ri< 0.45. The oxygen used under higher pressure -- oxygen as a drug , may have an extraordinary significance for better outcome of pregnancy implantation by improving endometrial receptivity. If endometrial receptivity is conditioned by adequate vascularisation and oxygenation, then hyperbaric oxygen therapy is the treatment of choice. PMID: 16879108 המאמרים מציינים בין היתר שיתכן שלטיפול יהיה ערך מוסף בקבוצת נשים עם פרוגנוזה גרועה,אולם יהיה צורך במאמרים נוספים לבסס את ההנחה,מאמר אחר מצא שיפול בהורמון האנטימילרייאלני המבטא את מצב רזרבת השחלה,כך שיתכן ערך מוסף בטיפול ההיפרבארי בנשים עם עם רזרבה נמוכה שערך ההורמון קטן מ-1,בגברים עם בדיקת הלוספרם נמוכה המבטאת שיעור שברים גבוהה ב-DNA של תאי הזרע נמצא שטיפול בתא חמצן משפר את איכות הזרע ומקטין את שיעור השברים ומכאן עשוי לשפר את שיעורי ההפריה ,איכות העוברים,וההשתרשות.ולבסוף,יתכן וטיפול כזה עשוי לשפר את איכות רירית הרחם ולשפר את תוצאות ההשתרשות

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